A nutrient dense diet is considered to be optimal to encourage health and vitality for all, irrespective of disease or disorder. As an integrated, dynamic and evolving system the human body requires a myriad of vitamins, minerals and other chemical compounds to preserve proper functioning of these systems.
Multinutrient formulas are beneficial to help encourage this nutrient density for diabetics1.
Specific Efficacy of Selected Ingredients:
- Bioflavonoids may encourage improved glycaemic control in diabetics2.
- Inulin has been shown to reduce total and LDL cholesterol in those with elevated cholesterol3 4 a common occurrence in diabetics. Animal studies suggest that inulin may also reduce hypertriglyceridaemia resulting from fructose intake5. Inulin may reduce post-prandial grhelin levels in comparison to starches6.
- Alpha-lipoic acid may encourage greater insulin sensitivity in those with type ll diabetes7, especially when combined with exercise8, and animal research suggests a potential for a prophylactic effect9.
- Cocoa extracts may offer a protective effect against oxidative stress in diabetics10 11.
- Astagalus may encourage insulin sensitivity in animal models12.
- Policosanol has demonstrated the ability to reduce LDL, increase HDL and reduce total cholesterol in patients with Type ll diabetes13.
- Magnesium may inhibit the development of cardiovascular complications (such as peripheral ulcers14) in diabetes and appears to play an important role in the regulation of blood glucose15 16.
- Thiamine supplementation may improve fasting and post-prandial glucose levels in type ll diabetics17.
- High homocysteine levels are thought to contribute to increased blood pressure. Higher folate levels have been demonstrated to reduce homocysteine levels and systemic stress18 and Mean Arterial Pressure in diabetics19.
- Higher dose biotin supplements may also offer protection against diabetes20 and may work synergistically with chromium21.
- The importance of chromium for optimal blood glucose is well known. Chromium supplementation has shown improved glycaemic control in diabetic patients22 animal studies demonstrate dramatic improvements in carbohydrate and lipid metabolism23.
- Clinical evidence suggests ginger improves glycaemic control and lipid profiles 24.
- Research on rat subjects demonstrate that treatment with probiotics improves memory impairment and cognitive function in diabetes25.
Multi-nutrient formulas rich in fruits, vegetable and berry extracts, medicinal herbs and vitamins and minerals offer a useful adjunct nutritional support for those with diabetes.
1. Farvid MS, Siassi F, Jalali M, Hosseini M, Saadat N. The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. Diabetes Research and Clinical Practice. 2004 7//;65(1):21-8.
2. Yilmazer-Musa M, Tucker AM, Frei B. Inhibition of α-amylase and α-glucosidase Activity by Bioflavonoids: Implications for Carbohydrate Metabolism and type 2 Diabetes. Free Radical Biology and Medicine. 2010 //;49, Supplement(0):S37.
3. Davidson MH, Maki KC, Synecki C, Torri SA, Drennan KB. Effects of dietary inulin on serum lipids in men and women with hypercholesterolemia. Nutrition Research. 1998 3//;18(3):503-17.
4. Causey JL, Feirtag JM, Gallaher DD, Tungland BC, Slavin JL. Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men. Nutrition Research. 2000 2//;20(2):191-201.
5. Rault-Nania M-H, Demougeot C, Gueux E, Berthelot A, Dzimira S, Rayssiguier Y, et al. Inulin supplementation prevents high fructose diet-induced hypertension in rats. Clinical Nutrition. 2008 4//;27(2):276-82.
6. Tarini J, Wolever TMS. Inulin increases postprandial serum short-chain fatty acids and reduces free fatty acids and ghrelin in healthy subjects: possible mechanisms by which dietary fibre reduces risk for type 2 diabetes. Canadian Journal of Diabetes. 2009 //;33(3):219-20.
7. Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, et al. Oral administration of rac-α-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology and Medicine. 1999 8//;27(3–4):309-14.
8. Henriksen EJ. Exercise training and the antioxidant α-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radical Biology and Medicine. 2006 1/1/;40(1):3-12.
9. Song K-H, Lee WJ, Koh J-M, Kim HS, Youn J-Y, Park H-S, et al. α-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochemical and Biophysical Research Communications. 2004 12/31/;326(1):197-202.
10. Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, et al. (−)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. International Journal of Cardiology. (0).
11. Campia U, Panza JA. Flavanol-Rich Cocoa: A Promising New Dietary Intervention to Reduce Cardiovascular Risk in Type 2 Diabetes? Journal of the American College of Cardiology. 2008 6/3/;51(22):2150-2.
12. Wang N, Zhang D, Mao X, Zou F, Jin H, Ouyang J. Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes. Molecular and Cellular Endocrinology. 2009 8/13/;307(1–2):89-98.
13. Crespo N, Alvarez R, Más R, Illnait J, Fernández L, Fernández JC. Effects of policosanol on patients with non—insulin-dependent diabetes mellitus and hypercholesterolemia: a pilot study. Current Therapeutic Research. 1997 1//;58(1):44-51.
14. Rodrı́guez-Morán M, Guerrero-Romero F. Low Serum Magnesium Levels and Foot Ulcers in Subjects with Type 2 Diabetes. Archives of Medical Research. 2001 7//;32(4):300-3.
15. Sales CH, Pedrosa LFC, Lima JG, Lemos TMAM, Colli C. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clinical Nutrition. 2011 6//;30(3):359-64.
16. Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Molecular Aspects of Medicine. 2003 2/6/;24(1–3):39-52.
17. Ramos-Zavala MG, González-Ortiz M, Ramírez-Ramírez V, Martínez-Abundis E, Robles-Cervantes JA. Effecf of oral administration of thiamine on serum markers inflammation in type 2 diabetes patients. Canadian Journal of Diabetes. 2009 //;33(3):219.
18. Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition. 2012 7//;28(7–8):e23-e6.
19. Fiorina P, Lanfredini M, Montanari A, Peca MG, Veronelli A, Mello A, et al. Plasma homocysteine and folate are related to arterial blood pressure in type 2 diabetes mellitus. American Journal of Hypertension. 1998 9//;11(9):1100-7.
20. McCarty MF. cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes. Medical Hypotheses. 2006 //;66(2):323-8.
21. McCarty MF. High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes. Medical Hypotheses. 1999 5//;52(5):401-6.
22. Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. Journal of Trace Elements in Medicine and Biology. 2011 7//;25(3):149-53.
23. Shinde UA, Sharma G, Xu YJ, Dhalla NS, Goyal RK. Insulin sensitising action of chromium picolinate in various experimental models of diabetes mellitus. Journal of Trace Elements in Medicine and Biology. 2004 9/14/;18(1):23-32.
24. Shivashankara AR, Haniadka R, Sandhya P, Palatty PL, Baliga MS. Chapter 44 - Ginger (Zingiber officinale Roscoe) in the Treatment of Diabetes and Metabolic Syndrome: Preclinical Observations. Bioactive Food as Dietary Interventions for Diabetes. San Diego: Academic Press; 2013. p. 571-82.
25. Davari S, Talaei SA, Alaei H, salami M. Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis. Neuroscience. 2013 6/14/;240(0):287-96.