[Post by Cliff Harvey ND]
A nutrient dense diet is considered to be optimal to encourage health and vitality for all, irrespective of disease or disorder. As an integrated, dynamic and evolving system the human body requires a myriad of vitamins, minerals and other chemical compounds to preserve proper functioning of these systems.
Multinutrient formulas are beneficial to help encourage this nutrient density for diabetics1.
Specific Efficacy of Selected Ingredients:
Multi-nutrient formulas rich in fruits, vegetable and berry extracts, medicinal herbs and vitamins and minerals offer a useful adjunct nutritional support for those with diabetes.
1. Farvid MS, Siassi F, Jalali M, Hosseini M, Saadat N. The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. Diabetes Research and Clinical Practice. 2004 7//;65(1):21-8.
2. Yilmazer-Musa M, Tucker AM, Frei B. Inhibition of α-amylase and α-glucosidase Activity by Bioflavonoids: Implications for Carbohydrate Metabolism and type 2 Diabetes. Free Radical Biology and Medicine. 2010 //;49, Supplement(0):S37.
3. Davidson MH, Maki KC, Synecki C, Torri SA, Drennan KB. Effects of dietary inulin on serum lipids in men and women with hypercholesterolemia. Nutrition Research. 1998 3//;18(3):503-17.
4. Causey JL, Feirtag JM, Gallaher DD, Tungland BC, Slavin JL. Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men. Nutrition Research. 2000 2//;20(2):191-201.
5. Rault-Nania M-H, Demougeot C, Gueux E, Berthelot A, Dzimira S, Rayssiguier Y, et al. Inulin supplementation prevents high fructose diet-induced hypertension in rats. Clinical Nutrition. 2008 4//;27(2):276-82.
6. Tarini J, Wolever TMS. Inulin increases postprandial serum short-chain fatty acids and reduces free fatty acids and ghrelin in healthy subjects: possible mechanisms by which dietary fibre reduces risk for type 2 diabetes. Canadian Journal of Diabetes. 2009 //;33(3):219-20.
7. Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, et al. Oral administration of rac-α-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radical Biology and Medicine. 1999 8//;27(3–4):309-14.
8. Henriksen EJ. Exercise training and the antioxidant α-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radical Biology and Medicine. 2006 1/1/;40(1):3-12.
9. Song K-H, Lee WJ, Koh J-M, Kim HS, Youn J-Y, Park H-S, et al. α-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochemical and Biophysical Research Communications. 2004 12/31/;326(1):197-202.
10. Ramirez-Sanchez I, Taub PR, Ciaraldi TP, Nogueira L, Coe T, Perkins G, et al. (−)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. International Journal of Cardiology. (0).
11. Campia U, Panza JA. Flavanol-Rich Cocoa: A Promising New Dietary Intervention to Reduce Cardiovascular Risk in Type 2 Diabetes? Journal of the American College of Cardiology. 2008 6/3/;51(22):2150-2.
12. Wang N, Zhang D, Mao X, Zou F, Jin H, Ouyang J. Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes. Molecular and Cellular Endocrinology. 2009 8/13/;307(1–2):89-98.
13. Crespo N, Alvarez R, Más R, Illnait J, Fernández L, Fernández JC. Effects of policosanol on patients with non—insulin-dependent diabetes mellitus and hypercholesterolemia: a pilot study. Current Therapeutic Research. 1997 1//;58(1):44-51.
14. Rodrı́guez-Morán M, Guerrero-Romero F. Low Serum Magnesium Levels and Foot Ulcers in Subjects with Type 2 Diabetes. Archives of Medical Research. 2001 7//;32(4):300-3.
15. Sales CH, Pedrosa LFC, Lima JG, Lemos TMAM, Colli C. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clinical Nutrition. 2011 6//;30(3):359-64.
16. Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Molecular Aspects of Medicine. 2003 2/6/;24(1–3):39-52.
17. Ramos-Zavala MG, González-Ortiz M, Ramírez-Ramírez V, Martínez-Abundis E, Robles-Cervantes JA. Effecf of oral administration of thiamine on serum markers inflammation in type 2 diabetes patients. Canadian Journal of Diabetes. 2009 //;33(3):219.
18. Al-Maskari MY, Waly MI, Ali A, Al-Shuaibi YS, Ouhtit A. Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes. Nutrition. 2012 7//;28(7–8):e23-e6.
19. Fiorina P, Lanfredini M, Montanari A, Peca MG, Veronelli A, Mello A, et al. Plasma homocysteine and folate are related to arterial blood pressure in type 2 diabetes mellitus. American Journal of Hypertension. 1998 9//;11(9):1100-7.
20. McCarty MF. cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes. Medical Hypotheses. 2006 //;66(2):323-8.
21. McCarty MF. High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes. Medical Hypotheses. 1999 5//;52(5):401-6.
22. Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. Journal of Trace Elements in Medicine and Biology. 2011 7//;25(3):149-53.
23. Shinde UA, Sharma G, Xu YJ, Dhalla NS, Goyal RK. Insulin sensitising action of chromium picolinate in various experimental models of diabetes mellitus. Journal of Trace Elements in Medicine and Biology. 2004 9/14/;18(1):23-32.
24. Shivashankara AR, Haniadka R, Sandhya P, Palatty PL, Baliga MS. Chapter 44 - Ginger (Zingiber officinale Roscoe) in the Treatment of Diabetes and Metabolic Syndrome: Preclinical Observations. Bioactive Food as Dietary Interventions for Diabetes. San Diego: Academic Press; 2013. p. 571-82.
25. Davari S, Talaei SA, Alaei H, salami M. Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: Behavioral and electrophysiological proofs for microbiome–gut–brain axis. Neuroscience. 2013 6/14/;240(0):287-96.
[Post by Professor Grant Schofield]
You’d care because being insulin resistance combined with a moderate to high carbohydrate diet makes you “hyperinsulinemic” – you have high insulin all the time.
This means you are now metabolically dysregulated meaning your body:
That’s why we care about insulin resistance and maybe you should too…..read on
What is insulin?Insulin is a protein produced by the pancreas. It helps in the regulation of nutrients and energy around the body. It is best known for helping move glucose (carbs) into cells so it can be used for energy. That’s a pretty crucial function; without insulin you will die. Type 1 diabetes is a failure of the pancreas to produce insulin, so Type 1 diabetics can inject synthetic insulin.
But insulin is way more interesting than just that. It is part of a complex hormonal and neural system that affects all parts of our body. That system controls energy storage and energy use. That system controls:
What is insulin resistance?
People are said to be insulin resistant when they have trouble getting glucose into their cells. One way to think about it is that the cells become “resistant” to insulin trying to open them up and get glucose in. This can be temporary – for example when we starve ourselves our body wants to divert any glucose away from most cells in the body and have it used by some cells which require more glucose (e.g, brain cells, red blood cells). In the meantime the rest of the body runs off fat. The same is true when we eat excessive amounts of carbohydrates. We can become temporarily insulin resistant, helping us pack away that extra energy into fat for a famine in the future.
When the body is properly regulated, the whole metabolic machine works perfectly. We produce insulin when we need to, become insulin resistant to help us when we are starving, and store extra energy when we are in times of plenty. In an evolutionary sense, this is a system designed to work across feast and famine.
Unfortunately the whole system can become “uncoupled” by modern life...
Stress, lack of famine and constant feast, too little exercise, poor quality foods and much more all make you insulin resistant. Modern human life promotes insulin resistance. In fact, my colleagues at Otago University have shown that in older New Zealanders, pre-diabetes may affect as much as 50% of the populaiton.
I’d say that this condition called “pre-diabetes” really indicates the start of “end stage” failure of the body. This is because pre-diabetes is the point where people start to be unable to get glucose into their cells, regardless of how much insulin they produce OR their pancreas has started to fail because of having to produce so much insulin for so long (it’s burnt out), then we can be almost certain that the majority of the older and other higher risk groups (Maori and Pacific people in New Zealand) are insulin resistant.
We need to identify insulin resistance way before you start to fail the tests your doctor currently uses. We’ll look at that now.
How can you tell if you are insulin resistant?
The main reason I wrote this post was because I am often asked how you tell if you are insulin resistant. That’s a great question and hard to answer, but very very important to your health. Read on.
The health system has some serious diagnostics which will show you if you are insulin resistant. I’ve listed everything below. You’ll know some of these already .
So these are the techniques your doctor will use to screen you to understand whether you have Type 2 diabetes or pre-diabetes. All of these by definition indicate moderate to severe insulin resistance, which has probably been persistent for decades.
But it’s not the end of the story. The problem is that you can pass any one of these tests fine but still have insulin resistance and all the problems described above.
Why? Because current medical testing looks at our inability to get glucose into cells, rather than how much insulin we are producing. Many people can move glucose into their cells at an acceptable rate but need to do so with massive amounts of insulin.
Therein lies the biggest unnoticed problem in modern medicine. We have a large part of the population told they are metabolically healthy when they are not. We send them away, tell them all is good, and it is only when they show “end stage” symptoms that we act.
Do you see a problem?
Bottom line 1: High and prolonged levels of insulin because of carbohydrates ingested, even with normal blood glucose responses, is dangerous to your health.
There is a better way – that is measuring both insulin and glucose response in the oral glucose tolerance test. That way we can see if you have this condition called “hyperinsulinemia” even with good glucose disposal. The trouble is that would cost you nearly $1000 in New Zealand, if you could find someone willing to do it and interpret the results. It’s costly, time consuming (a few hours in a lab) and messy and painful (lots of blood samples).
You could measure fasting insulin – but I’m not convinced that most insulin resistant people show problems here.
But can you observe symptoms yourself without a clinical diagnosis?
I think if you have a few of the symptoms below then it is likely you have insulin resistance.
Bottom line 2: If you have some of these symptoms, the easy “try it yourself” work around is to severely restrict the amount of carbohydrate you eat for a couple of weeks and see how you feel. I’d say if you are insulin resistant, then the carb restriction is the method which can best help you reset your metabolism.
More by and about Professor Grant Schofield can be found at his blog: www.profgrant.com
Research and popular science articles by the members and faculty of the Holistic Performance Institute.